Short version: amyloid matters, but it is not the whole disease. The National Institute on Aging says Alzheimer’s involves beta-amyloid plaques, tau, inflammation, and other biology, which is why decades of anti-amyloid drugs produced many failures or only modest benefit. Timing also matters. Once brain damage is advanced, removing plaque does not restore lost neurons.
The newer anti-amyloid drugs, like lecanemab and donanemab, are approved for early Alzheimer’s and can slow decline somewhat, but they do not reverse the disease. That is why the field is moving toward earlier treatment and a broader target list instead of betting everything on one protein.
Sources
This is general information, not professional medical advice. For decisions about your situation, talk to a qualified professional.
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