The best way to prevent motion sickness is to reduce the sensory mismatch that causes it. On a plane, that usually means choosing a seat with less motion if you can, looking outside when possible, keeping your head still, and avoiding reading or scrolling on your phone for long stretches.
What you eat matters too. A huge greasy meal, too much alcohol, or dehydration can make the problem worse. Small bland snacks and water are usually a safer bet if you know you are prone to nausea.
If motion sickness is a regular problem, medications like meclizine or scopolamine can help, but they are not magic and can cause drowsiness or other side effects. If you know you are a bad flyer, test what works before a big trip instead of discovering it at takeoff.
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